Caroline Coisne



Caroline Coisne (Post-doctorante)

Tel: 03 21 79 17 10



A stable and reproducible human blood-brain barrier model derived from hematopoietic stem cells.

Cecchelli R, Aday S, Sevin E, Almeida C, Culot M, Dehouck L, Coisne C, Engelhardt B, Dehouck M-P, Ferreira L.

PLOS ONE., 2014. Accepted

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PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE. 

Sathiyanadan K, Coisne C, Enzmann G, Deutsch U, Engelhardt B.

Eur J Immunol., 2014 Apr 16. [Epub ahead of print]. 

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Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo.

Coisne C, Lyck R, Engelhardt B.

Fluids Barriers CNS., 2013 Jan 21;10(1):7

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Tight junctions in brain barriers during central nervous system inflammation.

Coisne C, Engelhardt B.

Antioxid Redox Signal., 2011 Sep 1;15(5):1285-303

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Comparison of immortalized bEnd5 and primary mouse brain microvascular endothelial cells as in vitro blood-brain barrier models for the study of T cell extravasation.

Steiner O, Coisne C, Engelhardt B, Lyck R.

J Cereb Blood Flow Metab., 2011 Jan;31(1):315-27

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Fluids and barriers of the CNS establish immune privilege by confining immune surveillance to a two-walled castle moat surrounding the CNS castle.

Engelhardt B, Coisne C.

Fluids Barriers CNS., 2011 Jan 18;8(1):4

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Pre-clinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo. 

Coisne C, Engelhardt B.

Methods Mol Biol., 2010 ; 616:268-81

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Differential roles for endothelial ICAM-1, ICAM-2, and VCAM-1 in shear-resistant T cell arrest, polarization, and directed crawling on blood-brain barrier endothelium.

Steiner O, Coisne C, Cecchelli R, Boscacci R, Deutsch U, Engelhardt B, Lyck R.

J Immunol., 2010 Oct 15;185(8):4846-55

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Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis.

Jain P*, Coisne C*, Enzmann G, Rottapel R, Engelhardt B.

J Immunol., 2010 Jun 15;184(12):7196-206.* equal contribution

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Preclinical testing of strategies for therapeutic targeting of human T-cell trafficking in vivo.

Coisne C, Engelhardt B.

Methods Mol Biol., 2010;616:268-81

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Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis.

Coisne C, Mao W, Engelhardt B.

J Immunol., 2009 May 15;182(10):5909-13

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C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE.

Reboldi A, Coisne C, Baumjohann D, Benvenuto F, Bottinelli D, Lira S, Uccelli A, Lanzavecchia A, Engelhardt B, Sallusto F.

Nat Immunol., 2009 May;10(5):514-23

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Beta1 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity.

Bauer M, Brakebusch C, Coisne C, Sixt M, Wekerle H, Engelhardt B, Fässler R.

Proc Natl Acad Sci U S A., 2009 Feb 10;106(6):1920-5

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Therapeutic targeting of leukocyte trafficking across the blood-brain barrier.

Coisne C, Lyck R, Engelhardt B.

Inflamm Allergy Drug Targets., 2007 Dec;6(4):210-22

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Modeling the blood-brain barrier. Blood-Brain Interfaces-From Ontogeny to Artificial Barriers.

Cecchelli R, Coisne C, Dehouck L, Miller F, Dehouck M-P, Buée-Scherrer V, Dehouck B.

Edited by Dermietzel, Spray and Nedergaard. Wiley-VCH, Weinheim., 2006

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Response to Pachter and Song’s comments.

Coisne C, Dehouck B.

Lab. Invest., 2005 (85): 1441-1452

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